Buffalo quarterback Dustin Vaughan tied a season-high with five touchdown passes, going 28-of-37 through the air for 331 yards and the handful of scores.
The Buffaloes (8-1) used a 24-0 second-half outburst to take control of the game and then put it away down the stretch of the second half.
West Georgia (3-5) cut the lead to 10 points midway through the third quarter on a three-yard touchdown run by freshman quarterback Dallas Dickey, making it a 31-21 contest with 6:57 left in the third.
On the ensuing possession, Vaughan's pass was tipped at the line of scrimmage and picked off by Tyrell Adams, giving the Wolves the ball at the A&M 34 with 6:43 remaining in the third with a chance to build some momentum and cut the lead to single digits.
But two plays later, the Buffaloes got the ball right back when Dickey was sacked and fumbled, turning the ball back over to A&M at the UWG 46-yard line.
Vaughan went to work immediately, firing a 46-yard touchdown strike to Torrence Allen on the first play following the fumble to stretch the score to 38-21.
West Georgia answered when Dickey hooked up with Joey Eliezer on a 33-yard touchdown pass, making it a 10-point game again at 38-28 with 1:21 left in the third quarter.
From there, it was too much Vaughan and the Buffalo air attack, as the junior struck Sidney Parker on a one-yard score with 12:26 left in the game to tie his season-high mark of five touchdown passes.
West Texas A&M tacked on a four-yard Geremy Alridge touchdown run with 5:24 left in the game for the final tally.
The Buffaloes finished with 463 yards of total offense.
West Georgia jumped out to an early 14-7 lead before the big second-quarter stretch from the Buffaloes, who took a 31-14 lead into the locker room.
West Georgia moved the ball well in the first quarter, leading to a two-yard touchdown pass from Dickey to David Bailey and a three-yard Bailey touchdown run.
Dickey completed 7-of-10 pass attempts for 112 yards and two touchdowns, while rushing for 56 yards and a score on 19 carries.
Bailey led UWG on the ground, picking up 70 yards and a touchdown on 17 carries.
West Georgia has its home finale next week when it welcomes Shorter College to University Stadium for a 2 p.m. kickoff.